Mourinho has named eight players who could make their debuts in his squad for Sunday’s last Premier League game of the season against Crystal Palace.
“To play so many kids at the same time, honestly, I don’t think is good. You want them to be surrounded by players who support them,” said the Portuguese.
United are guaranteed sixth place, while Palace are safe from relegation.
Sam Allardyce’s side are 13th going into the match at Old Trafford (15:00 BST kick-off), but a victory and other results going their way could see them finish as high as 11th.
Mourinho’s side face Ajax in the Europa League final in Stockholm on Wednesday knowing victory will earn them a place in the group stages of next season’s Champions League.
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